1/03/2019

Can blood collection measure the biological clock? Multinational researchers explore new methods for detecting biological clocks


Everyone has their own unique set of biological clocks. At present, many national researchers are trying to develop a new method to quickly detect the human body clock, in order to better understand the human body and ensure health.

The biological clock is a system that controls the daily biological rhythm in the body, helping to regulate about 40% of the human body's genetic activities, and the "rhythm arrangement" of sleep, eating, body temperature, blood pressure, etc. are all related to it. A common method of measuring the body clock is to monitor changes in melatonin concentration in the human body. However, this method requires the subject to sit in the dark room for a long time and collect blood or saliva samples every hour or so.

In the new issue of Scientific American magazine, in order to develop more convenient, accurate and inexpensive detection methods, three teams in the world are currently stepping up research, and they have chosen the same research direction, that is, by measuring blood. Changes in the ribonucleic acid are used to assess gene activity, and then machine learning algorithms are used to calculate which genes are better able to reveal human rhythms.

At present, each research team has been able to measure the body clock only once or twice. The test method developed by the team led by Achim Kramer of the University Hospital of Shari, Germany, is very close to clinical application. The difference between the results measured by this method and the results measured using melatonin is only within half an hour.

Researchers say that the circadian clock disorder is associated with many diseases such as diabetes, heart disease, and depression. If you can find a convenient way to detect the body's biological clock, it will help people better understand and treat these diseases.

In addition, there are more uses for related detection methods, such as detecting whether people stay up late at night, and the accuracy rate is now over 90%. This allows the police to quickly determine if the driver is not getting enough sleep when dealing with a traffic accident, or to help check the pilot's suitability for a job with a higher safety requirement.

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